Highly Selective Inhibitors of  HDAC6 for the Treatment of Cancers  and Neurodegenerative disease front page preview

Highly Selective Inhibitors of HDAC6 for the Treatment of Cancers and Neurodegenerative disease

Researchers in RCSI and the Dana-Farber Cancer Institute have discovered a novel structural class of highly-selective HDAC6 inhibitors. These patented small molecules have a unique non hydroxamic acid chemical structure...

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FKBPL: A NOVEL TARGET FOR  OBESITY AND METABOLIC  SYNDROME front page preview

FKBPL: A NOVEL TARGET FOR OBESITY AND METABOLIC SYNDROME

RCSI researchers have discovered a novel target, FKBPL, which regulates energy expenditure, and have shown that obesity and Type 2 diabetes (T2D) develop when levels of this protein are low in mice and humans. Proof of...

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Novel Epigenetic Biomarkers and Targets for Metastatic Colorectal  Cancer front page preview

Novel Epigenetic Biomarkers and Targets for Metastatic Colorectal Cancer

Researchers at RCSI have developed a novel biomarker panel to identify patients with colorectal cancer who are at high risk of developing metastatic disease. The team are seeking industry partners to co-develop this pr...

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STARMAT – A Versatile Star  Polypeptide Platform for  Oligonucleotide Drug Delivery front page preview

STARMAT – A Versatile Star Polypeptide Platform for Oligonucleotide Drug Delivery

Star-polymers are a new class of polymer architecture which consist of linear arms radiating from a central core. Novel Star polypeptide-based vectors discovered at RCSI have superior transfection and delivery efficacy...

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A Novel Therapeutic Approach to Restore  Haemostasis in Individuals with Inherited  and Acquired Bleeding Disorders front page preview

A Novel Therapeutic Approach to Restore Haemostasis in Individuals with Inherited and Acquired Bleeding Disorders

RCSI has developed a novel therapeutic approach to restore haemostasis in individuals with haemophilia and other bleeding disorders by the inhibition of the initiation and activity of anticoagulant pathways mediated by ...

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